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The objectives of this research are: (1) to assess selected formulation-relevant physical properties of several commercial Feverfew extracts, including flowability, hygroscopicity, compressibility; compactibility (2) to develop; validate a suitable extraction method; HPLC assay,; (3) to determine the parthenolide content of several commercial Feverfew extracts. Carr’s index, minimum orifice diameter; particle-particle interaction were used to evaluate powder flowability. Hygroscopicity was evaluated by determining the equilibrium moisture content (EMC) after storage at various % relative humidities. Heckle analysis; compression pressure-radial tensile strength relationship were used to represent compression; compaction properties of feverfew extracts. An adapted analytical method was developed based on literature methods; then validated for the determination of parthenolide in feverfew. The commercial extracts tested exhibited poor to very poor flowability. The comparatively low mean yield pressure suggested that feverfew extracts deformed mainly plastically. Hygroscopicity; compactibility varied greatly with source. No commercial feverfew extracts tested contained the label claimed parthenolide. Even different batches from the same manufacturer showed significantly different parthenolide content. Therefore, extract manufactures should commit to proper quality control procedures that ensure accurate label claims,; supplement manufacturers should take into account possible differences in physico-chemical properties when using extracts from multiple suppliers.
Ping Jin1 Shadi Madieh1 Larry L. Augsburger1 Email:laugsbur@rx.umaryl .edu
[1] School of Pharmacy, University of Maryland, Baltimore, 20 N. Pine Street, Baltimore, MD 21201, USA ;[2] Present address: United States Pharmacopeia, 12601 Twinbrook Parkway, Rockville, MD 20852, USA ;[3] Present address: Glaxo Smith Kline, 709 Swedeland Road, UW2922, King of Prussia, PA 19406, USA