Welcome to Wordpublish.org Body!
The purpose of this research was to micronize beclomethasone-17,21-dipropionate (BDP), an anti-inflammatory inhaled corticosteroid commonly used to treat asthma, using the rapid expansion of supercritical solution (RESS) technique. The RESS technique was chosen for its ability to produce both micron particles of high purity for inhalation,; submicron/nano particles as a powder handling aid for use in next generation dry powder inhalers (DPIs). Particle formation experiments were carried out with a capillary RESS system to determine the effect of experimental conditions on the particle size distribution (PSD). The results indicated that the RESS process conditions strongly influenced the particle size; morphology; with the BDP mean particle size decreasing to sub-micron; nanometer dimensions. An increase in the following parameters, i.e. nozzle diameter, BDP mol fraction, system pressure,; system temperature; led to larger particle sizes. Aerodynamic diameters were estimated from the SEM data using three separate relations, which showed that the RESS technique is promising to produce particles suitable for pulmonary delivery.
Paul A. Charpentier1 Email:pcharpentier@eng.uwo.ca Ming Jia1 Rahima A. Lucky1
[1] Department of Chemical; Biochemical Engineering, University of Western Ontario, N6A 5B9 London, Ontario, Canada